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KMID : 0043319940170060420
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Archives of Pharmacal Research
1994 Volume.17 No. 6 p.420 ~ p.423
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Preparation of N’-Substituted Anilino-N-Methyl-N-Nitorsoureas as Candidate Antitumor Agents
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Kim Jack-C.
Kim Yeon-Gweon
Min Byoung-Tack
Park Jin-Il
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Abstract
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Various N’-substituted anilino-N-methyl-N’-nitrosoureas(2a-n) were easily prepared from the reaction of substituted phenylhydraines with methyl isocyanate, followed by the nitrosation with 99% HCOOH and dry sodium lnitrite powder. Surprisingly, of these series of analogus, the anilino-nitrocosureas substituted with eletron-withdrawing nitro groups (2k-a) showed significantly low values of In addition, none of these copounds subtituted with electron-donating groups exhibited cytotoxicities.
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KEYWORD
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N’-substituted anilono-N-methylurea, N′-substituted anilino-N-methyl-N′-nitrosurea, nitrosation of urea, antitumor acivity, L1210 cell
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